Unblinding Preclinical Studies- Enhance Reproducibility & Overcome the Translational Gap
Time: 2:30 pm
day: Conference Day 1
Details:
- Incorporating more of a clinical-type study design to preclinical research, i.e., well-powered, blinded, dose responsive for PK/PD, and predetermined translational readouts
- Using translational readouts including improvement in pathophysiological phenotype to improve probability of success
- Back-translation from clinical to preclinical to guide discovery
