Unblinding Preclinical Studies- Enhance Reproducibility & Overcome the Translational Gap

Time: 2:30 pm
day: Conference Day 1


  • Incorporating more of a clinical-type study design to preclinical research, i.e., well-powered, blinded, dose responsive for PK/PD, and predetermined translational readouts
  • Using translational readouts including improvement in pathophysiological phenotype to improve probability of success
  • Back-translation from clinical to preclinical to guide discovery